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ISCT Webinar: Media Use During Scale Up

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ISCT Webinar:  Media Use During Scale Up
Organized by the ISCT Immunotherapy Scientific Committee  


Chair: Patrick Hanley, PhD, Children's National Medical Center, USA

Jon Rowley, PhD, RoosterBio Inc, USA
Cor Lamers, PhD, Erasmus MC, Netherlands

About the Webinar:

Media is one of the many critical components used during cellular manufacture. With so many types of media, so many sources of protein, and with such a plethora of growth factors available, identifying the ideal source of media early on during scale up is of the essence. In this webinar, two leading experts in cellular therapy will discuss their experiences with media use during scale up in two different settings of cellular manufacture: mesenchymal stromal cells and T cells. More specifically, they will discuss why media formulations matter, how the type of culture system matters, how media use impacts not only material costs but also labor and facility costs, and how to compare different types of media.

Learning Objectives:

  • Learn why medium (formulation) does matter

  • Learn about medium requirements in static vs. high density culture

  • Identify how media impacts not only raw material cost, but also labor and facility costs and how to address in process development

  • Learn how to Streamline media use with comparability testing

  • Identify how strategic media formulation and system design for future scale up are possible with correct planning

  • Identify how changing media formulation can be a major process change, and should be performed early in clinical development if at all possible

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